Leadership Garegin Papoian
Ph.D.Co-Founder and CSO
Dr. Garegin Papoian is the Chief Scientific Officer of Deep Origin, with expertise spanning quantum chemistry, protein folding and dynamics, chromatin biophysics, cytoskeletal modeling, and whole-cell simulations. A former Monroe Martin Professor at the University of Maryland and Founder of Biosim (merged with Deep Origin), he earned his PhD at Cornell University under Nobel Laureate Dr. Roald Hoffmann. Dr. Papoian is widely recognized for his pioneering work in computational chemistry and biophysics, with more than one hundred publications in leading international journals and national honors including the Beckman Young Investigator Award, Camille Dreyfus Teacher-Scholar Award, and NSF CAREER Award.
Featured Publications
- Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945
- Feedback between F-actin organization and active stress governs criticality and energy localization in the cell cytoskeleton
- A tug of war between filament treadmilling and myosin induced contractility generates actin rings
- Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners
- AWSEM-IDP: A Coarse-Grained Force Field for Intrinsically Disordered Proteins
